The efficacy of this technique has been well established (Ross and Lawrence 1968, Crovitz 1969, 1971, Briggs, Hawkins and Crovitz 1970, Lea 1975), as is the minimal interference seen with its use. Retrieval of items is achieved by 'walking' through the loci, allowing the latter to activate the desired items. When desiring to remember a set of items the subject 'walks' through these loci in their imagination and commits an item to each one by forming an image between the item and any feature of that locus. In this technique the subject memorizes the layout of some building, or the arrangement of shops on a street, or any geographical entity which is composed of a number of discrete loci. 'the method of loci', an imaginal technique known to the ancient Greeks and Romans and described by Yates (1966) in her book The Art of Memory as well as by Luria (1969). The term is most often found in specialised works on psychology, neurobiology, and memory, though it was used in the same general way at least as early as the first half of the nineteenth century in works on rhetoric, logic, and philosophy. Many memory contest champions report using this technique to recall faces, digits, and lists of words.

This method is a mnemonic device adopted in ancient Roman and Greek rhetorical treatises (in the anonymous Rhetorica ad Herennium, Cicero's De Oratore, and Quintilian's Institutio Oratoria).

The method of loci is also known as the memory journey, memory palace, journey method, memory spaces, or mind palace technique. The method of loci is a strategy for memory enhancement, which uses visualizations of familiar spatial environments in order to enhance the recall of information. Cicero discussed the method of loci in his De Oratore.

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